Rozak cap. eye. solution fl. 5 ml

Drops eye Rozaky are applied to treatment of the increased intraocular pressure at patients with an open angle glaucoma or pseudo-exfoliative glaucoma when topical administration only of beta-blockers is insufficient.

Structure

1 ml of solution contains (active ingredients):

• dorzolamid - 20 mg in shape dorzolamidy a hydrochloride - 22.26 mg;
• Timololum - 5 mg in the form of Timololum of a maleate of 6.83 mg.

Excipients: a mannitol (E 421), sodium citrate, hydroxyethylcellulose, a benzalkoniya chloride, sodium hydroxide, water for injections.

Contraindication

Drug ​​ is contraindicated to patients with:

• reactive respiratory diseases, including bronchial asthma or bronchial asthma in the anamnesis, or a serious chronic obstructive illness of lungs;
• sinus bradycardia, a sick sinus syndrome, the sinuatrial block, atrioventricular block of II or III degree that is not controlled by a pacemaker, the expressed heart failure, cardiogenic shock;
• heavy renal failure (clearance of creatinine (CrCl) <30 ml/minute) or giperkhloremichesky acidosis;
• hypersensitivity to one or to two active ingredients or to any of medicine components and also during pregnancy and feeding by a breast.

on information on separate active components and are not specific to a combination.

Route of administration

If medicament ​​ is used as monotherapy, dug in on one drop in a sore eye (eyes) 2 times a day.

If at treatment use several local ophthalmologic drugs, then their application has to happen to an interval of at least 10 minutes.

At use of medicine needs to avoid contact of a dropper with the surface of an eye or skin around eyes. Otherwise to solution microorganisms which will entail an infection of an eye (eyes) can get. Use of kontaminirovanny solution can lead to heavy injuries of an eye, up to loss of sight.

Order of application of drops:

1. Before the first use of medicine that the bottle is supplied with an original tape.
2. to open a bottle, it is necessary to break off a tape, turning off a cover in the direction counterclockwise.
3. to Reject the head back and to delay a lower eyelid down that the gap between a century and an eyeball was formed.
4. to Turn a bottle and to press carefully until one drop of medicine gets into an eye. Easy pressing walls of a bottle is enough to measure one drop. It is not necessary to increase a dropper opening. It is not necessary to concern an eye dropper tip, a century and other surfaces.
If the doctor prescribed
5. to dig in medicine in other eye, it is necessary to repeat the actions specified in Paragraphs 3, 4.
6. After burying needs to twirl a bottle lid.

Feature of application

Pregnant women

do not use Drug during pregnancy.

whether it is removed dorzolamid in breast milk. Timololum cosecretes in breast milk therefore for treatment it is necessary to stop feeding by a breast.

Drug is not used by

to children.

Drivers

No researches of influence of medicine on ability to steer the vehicle or to work with mechanisms were conducted by

. Possible side reactions, such as illegibility of sight, can negatively affect ability of some patients to steer motor transport and to work with other mechanisms.

Overdose

Is not present data on overdose at people at accidental or deliberate ingestion of medicine.

Symptoms

Are available messages about inadvertent overdose of ophthalmologic solution of Timololum of a maleate as a result of which development of system effects, in particular dizzinesses, a headache, an asthma, bradycardia, a bronchospasm and cardiac arrest, similar it which are observed at overdose of beta blockers of system application is possible. Most often the expected symptoms at overdose dorzolamidy is violation of electrolytic balance, development of acidosis and potential impact on the central nervous system.

limited data on overdose at people at accidental or deliberate ingestion of a dorzolamid of a hydrochloride Exist. It was reported about drowsiness after oral administration. At topical administration it was reported about nausea, dizziness, a headache, weakness, unusual dreams and a dysphagy (the complicated swallowing).

Treatment

symptomatic treatment and supporting. It is necessary to control the level of electrolytes in blood serum (especially potassium) and indicators rn blood. Researches showed that Timololum is not removed completely at dialysis.

Side effects

In clinical trials of medicine ​​ side reactions which were observed corresponded to about what it was reported earlier at application of a dorzolamid of a hydrochloride and/or Timololum of a maleate.

As well as other ophthalmologic medicaments used locally, Timololum it is absorbed in a system blood-groove. It can lead to undesirable influence which like it that it is observed at application of system beta-blockers. Frequency of emergence of system side reactions on medicine after topical ophthalmologic administration is lower, than at system introduction.

O below-stated side reactions it was reported at use of medicine ​​ or one of its components in the course of clinical trials or post-marketing observation.

Frequency: very often (≥ 1/10), it is frequent (from ≥ 1/100 to <1/10), infrequently (from ≥ 1/1,000 to <1/100), is rare (from ≥ 1/10000 to <1/1000), frequency is unknown (it is impossible to estimate on the available data).

from organs of sight: very often - burning and pricking; often - a conjunctival injection, illegibility of sight, an erosion of a cornea, an itch in an eye, dacryagogue.

from the respiratory system, bodies of a thorax and mediastinum: seldom - sinusitis, short wind, respiratory insufficiency, rhinitis, a bronchospasm.

from digestive tract: very often - a dysgeusia (change of flavoring feelings).

from skin and hypodermic fabrics: seldom - contact dermatitis, Stephens-Johnson's syndrome, a toxic epidermal necrolysis.

from kidneys and urinary tract: infrequently - an urolithiasis.

to Store

in original packing at a temperature below 25 °C, out of children's reach.

Expiration date - 2 years (after the first opening - 4 weeks).