Proviron of the tab. of 25 mg No. 20

Pharmacological properties

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insufficiency of androgens which development snizhtsya gradually with age. thus proviron provides treatment of the states caused by insufficiency or total absence of development of androgens in an organism. in the recommended doses does not reduce a spermatogenesis. medicament has no hepatotoxicity.

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After oral administration mesterolon it is quickly and almost completely absorbed in the range of doses that makes 25–100 mg. The maximum concentration in serum — 3.1±1.1 ng/ml, is reached in 1.6±0.6 h after Proviron's reception. Considering it, the level of active ingredient in serum decreases with the final elimination half-life making 12–13 h 98% of a mesterolon contacts proteins of blood plasma, 40% of a mesterolon contact albumine and 58% — the globulin, connecting sex hormones (G,CSH).

Mesterolon is quickly metabolized by

. Speed of metabolic clearance is 4.4±1.6 ml/min. ^{-1 of serum} / kg ^-1 . It Eskskretirutsya by kidneys only in the form of metabolites. The main metabolite is 1α-метил-андростерон, in the conjugated form, making 55–70% of the metabolites which are excreted kidneys. A ratio of glucuronides of the main metabolite to sulfates about 12.1. Other metabolite is 1α-метил-5α-андростан-3α, 17β-диол, making about 3% of metabolites which are removed by kidneys. Any metabolic transformation into estrogen or kortikoida is noted. About 80% of a dose of a mesterolon are excreted in the form of metabolites with urine, and about 13% of a dose — with excrements. Within 7 days of 93% of a dose it was revealed in discharges which half was excreted with urine during 24 times.

Absolute bioavailability of a mesterolon is about 3% of an oral dose.

Oral administration of a daily dose of Proviron leads

to increase in level of substance in blood serum approximately for 30%.

Decrease in functional activity on average and advanced age

Proviron eliminates

Indication

or minimizes the complaints caused by insufficiency of androgens, such as reduced working capacity, fast fatigue, memory loss and abilities to concentrate, disturbance of a libido and potency, irritability, sleep disorders, depressions and psychovegetative disturbances.

Proviron eliminates with

disturbances of potency caused by insufficiency of androgens. If in the course of decrease in potency any other reasons play a role, prescribing of the medicament Proviron as additional tool in complex therapy is possible.

Hypogonadism

Proviron has the stimulating impact on growth, development and functioning of androgenzavisimy target organs. In case of insufficiency of androgens during the prepubertatny period Proviron contributes to the development in the man of secondary sexual characteristics. By means of Proviron, symptoms of insufficiency of androgens at depression of function of gonads after achievement of age of puberty are eliminated.

Causes of infertility the oligozoospermia and insufficient secretion by cells of Leydiga can be p>

. By means of the medicament Proviron it is possible to raise or normalize quantity and quality of spermatozoa and also concentration of fructose in an ejaculate that increases fertilization probability.

Use

Pill is taken whole without chewing, with enough liquid.

recommend the schemes of treatment provided below:

in case of decrease in functional activity and disturbances of potency

In an initiation of treatment:

on 1 tablet 3 times a day of Proviron. After achievement of improvement of a condition of the patient it is possible to try to reduce this dose.

Further treatment:

on 1 tablet Provirona of 1-2 times a day. Depending on a look and intensity of dysfunction or complaints it is necessary to pick up individually a dose for further treatment. Continuous continuation of treatment within several months is recommended.

in case of a hypogonadism needs long treatment:

for the purpose of stimulation of development of secondary sexual characteristics within several months on 1–2 tablets Provirona 3 times a day. As a maintenance dose it is enough to accept on 1 tablet of medicament 2–3 times a day.

in case of infertility for increase in quantity and quality of spermatozoa:

throughout a full cycle of a spermatogenesis, that is approximately within 90 days to accept on 1 tablet Provirona 2–3 times a day. In case of need it is necessary to repeat the treatment cycle after a break lasting several weeks. For increase in concentration of fructose in an ejaculate in case of insufficiency of cells of Leydiga during the post-pubertal period: for several months accept on 1 tablet Provirona 2 times a day.

Contraindication

Prostate cancer, liver tumors at present or in the anamnesis. hypersensitivity to active ingredient or any component of drug.

Side effects

frequent and too long erection In some cases can be observed, at the same time it is necessary to reduce a dose or to stop treatment in order to avoid complications owing to a long erection.

Androgens healthy faces cannot accept

for strengthening of muscles or increase in the general physical abilities.

Proviron is intended to

only for use by male patients.

to

for the purpose of prevention recommends periodic carrying out inspections of a prostate.

Caution at use

was very seldom observed by

After intake of the hormonelike materials which are a part of the medicament Proviron education benign, and is even even more rare — malignant tumors of a liver. In some cases intra belly bleeding, caused by such tumors, posed a threat of life. If the man who uses Proviron has a severe pain in an upper part of a stomach, increase in a liver or there are symptoms of intra belly bleeding, when performing differential diagnostics it is necessary to consider the probability of presence of a tumor of a liver.

are not described by

Interaction

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that medicament proviron can be regarded as non-toxic. even at accidental one-time reception of a dose which several times exceeds therapeutic, does not exist risk of toxicity.

At medicament overdose, along with the increased sexual excitement, appearance of dizziness, nausea, a delay of water and salts in an organism is possible

. The specified phenomena pass independently after a dose decline or medicament withdrawal.

Storage conditions

At a temperature not above 30 °C.