Merkana Aktiv of the capsule for normalization of a functional condition of joints a bottle of 20 pieces

Dietary Merkana Aktiv additive – promotes reduction of constraint of joints, improvement of their mobility and flexibility.

Active components

NEDENATUROVANNY COLLAGEN II of the UC-II® TYPE. Difference of not denatured collagen II of the UC-II type from denatured (or hydrolyzed) is preservation of a three-dimensional configuration of the molecule (not denatured type collagen II) and existence of active epitopes. It is considered that not denatured collagen II of the UC-II® type at oral administration gets from an intestines cavity into Peerovy plaques of intestines and promotes formation of specialized regulatory T lymphocytes (T-regulators) which are capable to produce anti-inflammatory tsitokiny1, such as IL-10), interleukin-4 (IL-4) and a transforming factor роста-β (TGF-β). These cytokines are capable to get into synovial fluid of a joint through the blood system of a synovial membrane and a subchondral bone.

Anti-inflammatory IL-10, IL-4, TGF-β cytokines are capable to inhibit inflammation and to improve metabolism of cartilaginous tissue. IL-10 influences receptors of macrophages and sinoviotsit, inhibiting release of interleukin-1 (IL-1). TGF-β stimulates synthesis of intercellular substance (matrix) of a cartilage due to oppression of catabolic activity of chondrocytes (that led to disintegration of collagen and other proteins of an extracellular matrix) and activation of anabolic function and proliferation of chondrocytes. Besides, IL-10 and TGF-β promote increase in products of interleukin-4 (IL-4). It promotes switching of metabolism of chondrocytes towards synthesis of components of an intercellular matrix. Researches established 1,2,3 that daily reception of 40 mg (mg) of not denatured collagen II of the UC-II type is capable to promote relief of discomfort in joints and also to restoration of their healthy function and flexibility. Also issledovaniyem2 it is established that daily reception of 40 mg (mg) of not denatured collagen II of the UC-II type within 90 days at certain states (for example, demanding restoration of cartilaginous tissue) can lead to more significant changes of indicators, than at use of a complex of a glycosamine (1500 mg (mg)/days) and chondroitin (1200 mg (mg)/days).

not denatured collagen II of the UC-II type promotes reduction of inflammation in joints and to improvement of metabolism of an articulate cartilage.

МЕРКАНА® the ASSET contains the patented complex of extract of a rhizome of a turmeric and pitches bosvet NovaSOL® Curcumin Boswellia. NovaSOL® – the patented German technology of placement of slaborastvorimy substances in 30-nanometer micelles which thus get lipo- and hydrophilic (at the same time a giro - and water-soluble, or amphiphilic) properties. The NovaSOL® technology increases the speed of absorption and bioavailability of the ingredients placed in micelles. About 185 times big bioavailability and up to 455 times higher maximum concentration in curcumine blood were shown at its oral administration in a micellar look in comparison with native kurkuminom4. Also the big bioavailability of the most active component of extract of a bosveliya - ацетил-11-кето-β-босвелиевой acids (AKBA) was shown by 56 times at oral administration of the dissolved bosvela extract in micelles in comparison with usual (native) extract bosveli5.

from pitch of a plant Bosveliya gear (Boswellia serrata). Components of pitch of a bosveliya gear are known as powerful anti-inflammatory, protivoartritny tool. The main active Boswellia serrata ingredients are bosveliyevy acids, of which six acids are main: ацетил-11-кето-β-босвелиевая acid (AKBA), 11-кето-β-босвелиевая acid, α-bosveliyevy acid, β-bosselevy, ацетил-α-босвелиевая acid and ацетил-β-босвелиевая acid.

In researches it was shown that these acids are capable to inhibit a number of the main enzymes of inflammation (5 lipoxygenase (5-LO), cathepsine G (catG) and microsomal prostaglandin-E-sintaza (mPGES) - 1) and also – a transkriptsionny nuclear factor κB (NF-κB) and several pro-inflammatory cytokines (a factor of necrosis of tumors (TNF-α), интерлейкин-1β (IL-1β), interleukin-2 (IL-2) and interleukin-6 (IL-6)).

Atsetil-11-keto-β-bosveliyevaya acid (AKBA) is the most active compound of extract of a bosveliya and represents powerful inhibitor 5 of a lipoxygenase (5-LO), key enzyme in biosynthesis of leukotrienes from arachidonic acid in a cellular inflammatory cascade. In a number of clinical trials, anti-inflammatory and protivoartritny properties of extract of a bosveliya were confirmed.

TURMERIC EXTRACT which is part МЕРКАНА® the ASSET, received from a plant rhizome the Turmeric long (Curcuma longa) contains various components among which are better known curcumine, essential oils, δ-элландрен, tsingiberen, sabinene. Curcumine is the most studied in terms of use in medicine and has antioxidant, anti-inflammatory, antidiabetic and cardiotyre-tread properties.

Curcumine is the most active ingredient of the extract of a turmeric used as anti-inflammatory and antioxidant drug. In researches its anti-inflammatory property in a look at

oppression of production of pro-inflammatory cytokines (IL-1, IL-6 interleukins, etc.), a factor of necrosis of tumors (TNF-α), oppression of a transkriptsionny nuclear factor κB (NF-κB), inhibition of pro-inflammatory enzymes (cyclooxygenase-2 (TsOG-2), 5 lipoxygenases (5-LO) and indutsibelny synthase of nitrogen oxide (iNOS) that leads to decrease in level of E2 (PGE2) prostaglandin and nitrogen oxide (NO).

Thus, natural extracts of a turmeric and a bosveliya are well-known the anti-inflammatory activity.

D3 (CHOLECALCIFEROL) VITAMIN. Active forms of vitamin D participate in regulation of phosphorus-calcium exchange. Vitamin D stimulates absorption of calcium ions and phosphate with an intestines wall, stimulates a reabsorption of calcium and phosphate in renal tubules. Vitamin D is necessary for functioning of epithelial bodies, intestines, kidneys and providing a mineralization of a bone tissue. Concentration of calcium ions influences a number of the important biochemical processes causing maintenance of a tone of the muscles of skeletal muscles participating in carrying out nervous excitement and affecting blood clotting. In researches the ability of vitamin D to reduce an erosion of an articulate cartilage, to reduce the level of the enzymes destroying cartilaginous and bone collagen (matriksny metalloproteinase 9 and 13 (MMP-9 and MMP-13)) with simultaneous increase in level of a transforming factor of growth (TGF-β is also shown. Some clinical trials showed decrease in discomfort and improvement of function of knee joints at vitamin D use.

ASSET Capsule Merkan on special technology of zhidkosoderzhashchy Licaps® solid capsules * that provides protection of contents of the capsule against course and external influence. Besides, the cover of the Licaps® capsule provides its faster dissolution for acceleration of absorption of active agents of contents of the capsule.

Indications

МЕРКАНА® the ASSET it is recommended as dietary additive to a food allowance as an additional source of not denatured collagen II of type (UC-II®), bosveliyevy acids, kurkuminoid and vitamin D (cholecalciferol) for the purpose of improvement of a condition of joints, normalization of a functional condition of joints, in particular, to loading. Promotes elimination of inflammation and reduction of constraint of joints, improvement of their mobility and flexibility.

to Use

adult on 1 capsule 2 times a day in 2 hours prior to or in 2 hours after a meal, washing down with a glass of drinking water. Before use the consultation of the doctor is recommended. The minimum course of consumption makes 10 days, if necessary the course can be repeated.

According to the recommendation of the doctor consumption can be prolonged within 6 months.

Feature of use

not to exceed the recommended daily dose. МЕРКАНА® the ASSET should not be used as replacement of an adequate diet of food. It is important to follow rules of the various, balanced food and healthy lifestyle.

Contraindication

Individual sensitivity to any of components, pregnancy and the period of feeding by a breast.

1 capsule contains

: active ingredients:

• extract of a rhizome of a turmeric and pitch of a bosveliya (NovaSOL®* Curcumin Boswellia) – 829.566 mg (mg) (containing min. 3% of kurkuminoid and min. 6% of bosveliyevy acids);
• collagen which is not denatured the II type (UC-II® *) – 20.0 mg (mg);
• Vitamin D (cholecalciferol) – 7.5 mkg (µg) (that corresponds to 300 ME);
• other components: emulsifiers: polysorbates (E433, E432), stabilizer: potassium chloride (E508); Capsule Cover: hydroksipropilmetiltsellyuloz (E464).

Storage conditions

to Store

in original packing at a temperature from 4 to 25 °C in dry, protected from light and the place, inaccessible for children.