HartMedin by Cymedica - Tablets for treatment of heart failure at dogs

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Description

It is frequent, chetverolapy favourites face heart failure. Reasons of development of pathology set: predisposition of breed, obesity, the wrong way of life or the postponed diseases. Modern Czech medicine Hart Medin, helps with therapy of pathologies of heart and considerably facilitates a condition of an animal. Medicine is regularly highly appreciated by veterinarians and experienced manufacturers. The convenient form of release considerably facilitates drug intake and will not cause difficulties in the owner. HartMedin tablets apply

orally to treatment of warmly vascular diseases at dogs.

Indication to application is the heart failure caused by a dilatatsionny kardiomionatiya, insufficiency of the two-fold or three-leaved valve which is followed by characteristic symptoms: cough, short wind, decrease of the activity or ascites.

increased by ability of heart to pump over blood.
it is used at stagnant heart failure at dogs because of insufficiency of the atrioventricular valve or at a dilatatsionny cardiomyopathy.
pimobendan higher effect on life expectancy of the patient in relation to a benzaperil at HSN caused by degenerative anomaly of the mitralny valve
universal and economic dosage of tablets from 1.25 to 10 mg

Instruction:

HartMedin mg tablets 2.5 and 10

Packing of 2.5 mg: Tablets in blisters on 4*15 pieces
Packing of 10 mg: Tablets in blisters on 3*10 pieces

Trade name of medicine: ХартМедин® tablets (HeartMedin® tablets).

International non-proprietary name: pimobendan.

Dosage form: tablet.

release

HartMedin® of a tablet in two dosages:

— tablets weighing 992 mg contain 10 mg of active ingredient of a pimobendan (10.4 mg of the micronized pimobendan in silicon oxide), and auxiliary components: citric acid waterless – 480 mg, F-Melt type M – 473.6 mg, silicon oxide — 16 mg and stearate of magnesium – 12 mg;

— tablets weighing 248 mg contain 2.5 mg of active ingredient of a pimobendan (2.6 mg of the micronized pimobendan in silicon oxide), and auxiliary components: citric acid of waterless –120 mg, F-Melt type M – 118.4 mg, silicon oxide — 4 mg and stearate of magnesium – 3 mg;

On appearance of HartMedin® of a tablet represents white oval tablets without covering from risky in the middle.

Medicine is packaged by

in the corresponding blisters. Blisters are packed into individual cardboard boxes:

Tablet of 2.5 mg packaged about 15 tablets in the blister which are packed into individual cardboard boxes on 2 (30 tablets) or 4 (60 tablets) the blister;

Tablet of 10 mg packaged about 10 tablets in the blister which are packed into individual cardboard boxes on 3 (30 tablets) or 6 (60 tablets) blisters;

HartMedin® of a tablet is stored at a temperature from 0 °C to 25 °C.

Expiration date – 3 years from the date of production.

Pharmacological properties

Pharmacotherapeutic group: cardiotonic means.

Pimobendan who is a part of the medicine HartMedin® of a tablet possesses positive inotropny action and the expressed vazodilatiruyushchy effect. Unlike cardiac glycosides the positive inotropny effect of medicine is caused by two mechanisms: increase in sensitivity to calcium of fibers of a cardiac muscle and oppression of phosphodiesterase III. The Vazodidatiruyushchy effect is connected with inhibition of activity of phosphodiesterase III. Thanks to existence of positive inotroiny and vazodilatiruyushchy action at heart failure medicine increases force of warm reductions and reduces both preloading, and post-loading.

After oral application pimobendan it is quickly soaked up in blood, and its bioavailability is 60-63%. The half-life period of a pimobendan in plasma of blood is 0.4±0.1 hours, and elimination half-life of its active metabolite makes 2.0±0.3 hours. The most part of metabolites of a pimobendan is brought out of an organism of animals with a stake.

HartMedin® of a tablet on extent of impact on an organism treat low-dangerous substances (the 4th hazard class in accordance with GOST 12.1.007-76), do not possess the sensibilizing, embriotoksichesky, teratogenny and mutagen action.

an application Order

HartMedin® of a tablet is applied orally to treatment of cardiovascular diseases at dogs. The indication to application is the heart failure caused by a dilatatsionny kardiomionatiya, insufficiency of the two-fold or three-leaved valve which is followed by characteristic symptoms: cough, short wind, decrease of the activity or ascites. It is forbidden to apply HartMedin® of a tablet at a hypertrophic cardiomyopathy and clinical states at which warm emission of blood because of functional or anatomic features cannot be increased (for example, an aorta stenosis).

forbids to use

HartMedin® of a tablet to dogs with severe damages of a liver as medicine mainly metabolizirustsya in a liver.

forbids combined use of HartMedin® of a tablet with blockers of calcic channels and a beta-blocker iropranololy as these substances weaken action of a pimobendan.

Dosage can fluctuate from 0.2 mg to 0.6 mg of a pimobendan on 1 kg of body weight a day according to the recommendation of the veterinarian and also depending on weight of a course of a disease and a condition of an animal. The daily dose is divided into two receptions (see the table):

		Quantity of tablets on reception
		Morning (a dose on reception)		Evening (a dose on reception)
Weight of an animal	Daily dose (mg)	2.5 mg	10 mg	2.5 mg	10 mg
5 — 10	2.5	½	—	½	—
11 — 20	5	1	—	1	—
21 — 40	10	—	½	—	½
41 — 60	20	—	1	—	1
> 60	30	—	1 ½	—	1 ½

apply

in case of stagnant heart failure of HartMedin® of a tablet an animal for life with selection of an individual dose.

HartMedin® of a tablet is given to an animal for an hour before feeding.

At overdose of medicine at an animal the vomiting, apathy, tachycardia, noise in heart and pressure decrease can be observed. In case of overdose it is necessary to stop giving medicine and to see the veterinarian. At the same time immediate use of adsorbents is recommended (for example, activated carbon).

Features of effect of medicine at its first application and cancellation it is not revealed.

Should avoid violations of the scheme of application of HartMedin® of a tablet as it can lead to decrease in efficiency. In case of the admission of the next intake of medicine it will be out in the same dose according to the same scheme.

At use of the medicine HartMedin® of a tablet according to the present instruction of by-effects and complications, as a rule, it is not observed.

At the increased individual sensitivity of an animal to components of medicine and development of allergic reactions use of medicine is stopped and carry out the desensibilizing and symptomatic therapy.

At application of HartMedin® of a tablet with blockers of calcic channels and a beta-blocker iropranololy action of a pimobendan will decrease.

Producer : Cymedica, Cymedica, spol. s r.o., Czech Republic

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