Geparin-Novofarm solution for infection. 5000 ME/ml fl. 5 ml No. 5

Solution for injections of Geparin-Novofarm is shown:

• At prevention and treatment of thromboembolic diseases and their complications.
• For prevention of postoperative venous thromboses and an embolism of a pulmonary artery at the patients who transferred abdominal or a Torah radical surgical interventions or at those who through any other reasons have risk of developing a clotting disease.
• For prevention of fibrillation at laboratory researches, dialysis, extracorporal blood circulation, heart surgeries and vessels, direct blood transfusion.

Structure

Active ingredient: heparin;

1 ml;

Excipients: benzyl alcohol, sodium chloride, water for injections.

Contraindication

• At hypersensitivity to heparin and/or alcohol of benzylic;
• In thrombocytopenia;
• At an entsefalomalyation;
• In a visceral carcinoma;
• In a serious illness of a pancreas;
• At suspicion on heparin the induced immune thrombocytopenia;
• In bleedings of any localization, except for the hemorrhage which arose because of an embolic heart attack of lungs or kidneys;
• In hemophilia;
• In repeated bleedings in the anamnesis, irrespective of their localization;
• At hyperpermeability of vessels;
• In uncontrollable heavy arterial hypertension,
• In a hemorrhagic stroke;
• In heavy abnormal liver functions and/or kidneys;
• At the menacing abortion;
• to Patients, were accepted by high doses of alcohol.

Route of administration

Geparin-Novofarm is appointed in the form of jet or faltering intravenous or subcutaneous injections. Before prescribing of medicine it is necessary to define a blood clotting time, the thrombin and activated partial tromboplastinovy time, quantity of platelets. The adult at sharp thrombosis treatment there begin with intravenous administration 10000 - 15000 ME Geparina-Novofarm under control of coagulation of venous blood, the thrombin and activated partial tromboplastinovy time. After that on 5000 - 10000 ME Geparina-Novofarm enter intravenously each 4-6 hours. At the same time the dose of Geparina-Novofarm at which the blood clotting time is extended by 2.5-3 times, and the activated partial tromboplastinovy time - by 1.5-2 times is considered adequate.

Feature of application

Pregnant

Expediency of use of medicine is solved individually taking into account a ratio advantage for mother / risk for a fruit.

Children

use Drug to children according to the mass of their body.

Drivers

does not influence.

At overdose the developing of bleedings is possible

.

Treatment. In insignificant bleedings there can be sufficient a dose decline of medicine or the temporary termination of its introduction. In considerable bleedings urgently cancel introduction of Geparina-Novofarm and appoint antidote - 1% sulfate protamin solution (enter slowly intravenously) from calculation that 1 mg of protamin of sulfate neutralizes 85 ME Geparina-Novofarm.

Side effects

• from mentality: depression.
• from nervous system: headache, dizziness.
• from digestive system: nausea, vomiting, diarrhea.
• from digestive system: increase in level of hepatic Transaminases - alaninaminotranspherases (ALT) and aspartate aminotransferases (ACT), lactate dehydrogenases, gamma glutamiltransferazy and a lipidemia.
• from skin and hypodermic cellulose: rash (erythematic, makulopapulezny), urticaria, an itch, an itch and burning in skin of feet, skin necrosis, a multiformny erythema, an alopecia.
• from the musculoskeletal system: osteoporosis, demineralization of bones.
• from a reproductive system: priapism.
• from the immune system: skin rash, conjunctivitis, dacryagogue, rhinitis, a bronchospasm, asthma, the Tachypnea, cyanosis, a small tortoiseshell, an allergic vasomotor spasm in extremities, anaphylactoid reactions, an acute anaphylaxis.

Interaction

Simultaneous consumption of alcoholic drinks can increase risk of developing bleedings considerably.

Danger also increases at simultaneous application of Geparina-Novofarm with ulcerogenic, immunosuppressive and thrombolytic medicines.

to Store

in the place protected from light at a temperature not above 25 °C.

to Store

out of children's reach.

Expiration date - 2 years.