But-x-sha soup. rektat. 0.04 g No. 10

But-x-sha will be appointed with the medical purpose at:

• spasms of smooth muscles connected with diseases of a biliary path: cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, papillitis;
• spasms of smooth muscles at diseases of an uric path: nephrolithiasis, ureterolithiasis, pyelitis, cystitis, bladder tenesmus.

as auxiliary treatment at:

• spasms of smooth muscles of digestive tract: a peptic ulcer of a stomach and a duodenum, gastritis, kardio and/or a pylorospasm, colitis, a spastic colitis with a constipation and a syndrome of the angry intestines which are followed by a meteorism;
• gynecologic diseases (dysmenorrhea).

Structure

active ingredient: Drotaverinum hydrochloride;

1 suppository contains hydrochloride Drotaverinum in terms of dry matter 0.04 g (40 mg);

excipient: solid fat.

Drotaverinum – derivative isoquinoline, has spasmolytic effect on smooth muscles by oppression of effect of enzyme of ІV phosphodiesterase (FDE ІV) that leads to increase in concentration of tsAMF and thanks to an inactivation of an easy link of a kinase of myosin (MLCK) leads to relaxation of an unstriated muscle.

at spasms of smooth muscles of both nervous, and muscular origin. Drotaverinum affects smooth muscles of gastrointestinal, biliary, urinogenital and vascular systems irrespective of type of their autonomous innervation.

It strengthens blood circulation in fabrics thanks to the ability to expand vessels.

Contraindication

Hypersensitivity to Drotaverinum or to any component of medicine. Heavy liver, renal or heart failure (syndrome of small warm emission).

Before application of a suppository it is necessary for

:

• through perforation of the blister packing to tear off 1 suppository in primary packing;
• needs to be pulled further for edges of a film, revealing her in different directions and to exempt a suppository from primary packing.

Drug is intended to

for rectal application.

for adults and children 12 years are more senior than

Dose – on 1 suppository 2 times a day. The doctor determines treatment duration individually.

by

Overdose

At considerable overdose by Drotaverinum observed violations of a warm rhythm and conductivity, including a total block of a ventriculonector and cardiac arrest which can be lethal.

At overdose the patient has to be under careful observation of the doctor and receive symptomatic treatment.

Side reactions

Side effect which was observed in the course of clinical trials and, perhaps, was caused by Drotaverinum, distributed on the system of bodies.

from the immune system: allergic reactions, including a Quincke's disease, a small tortoiseshell, rash, the naggers, a dermahemia, fever, a fever, fervescence, weakness.

from a cardiovascular system: cardiopalmus, arterial hypotension.

from nervous system: headache, dizziness, insomnia.

from digestive tract: nausea, lock, vomiting.

Feature of application

Use during pregnancy or feeding by a breast

Pregnancy. As showed results of clinical trials and researches on animals, use of Drotaverinum did not cause any signs of any direct or indirect impact on pregnancy, embryonic development, childbirth or postnatal development. However pregnant women need to appoint medicine with care.

feeding Period breast. Due to the lack of data during feeding the breast does not recommend to use drug.

Children

not to use Drug for treatment of children aged up to 12 years.

Ability to influence speed of response at control of motor transport or other mechanisms

If at patients after use of medicine is observed dizziness, they have to avoid potentially dangerous occupations, such as driving and performance of work requiring special attention.

Interaction with other medicines and other types of interactions

phosphodiesterase Inhibitors, such as papaverine, reduce antiparkinsonichesky effect of a levodopa. It is necessary to use with care medicament No-H-sha ^® along with a levodopa as the antiparkinsonichesky effect of the last decreases, and the rigidity and a tremor amplify.

to Store

out of children's reach in original packing at a temperature not above 25 °C.

Expiration date - 2 years.