Название документа
  • Ingaron lyof d / prig intranasal solution introduced 100 thousand IU bottle 1 pc.

Latin name

Ingaron


Release form

Lyophilisate for preparation of a solution for intranasal administration.


Package

1 bottle.


pharmachologic effect

Pharmacotherapeutic group


Immunomodulatory agent.


 


Pharmacological properties


INGARON® is a recombinant human interferon gamma, consists of 144 amino acid residues (a.a.), devoid of the first three amino acid residues. O. Cys-Tyr-Cys replaced by Met. Molecular weight 16.9 kDa. Obtained by microbiological synthesis in a recombinant Escherichia coli strain and purified by column chromatography. The specific antiviral activity on cells (human fibroblasts) infected with the vesicular stomatitis virus is 2 × 107 U per mg of protein. Interferon gamma (immune interferon) is the most important anti-inflammatory cytokine produced in the human body by natural killer cells, CD4Th1 cells and CD8 cytotoxic suppressor cells.


Receptors for interferon gamma have macrophages, neutrophils, natural killer cells, cytotoxic T-lymphocytes. It activates the effector functions of these cells, in particular their microbicidal, cytotoxicity, their production of cytokines, superoxide and nitroxide radicals (thereby causing the death of intracellular parasites). Interferon gamma blocks the replication of viral DNA and RNA, the synthesis of viral proteins and the assembly of mature viral particles. In this case, it causes a cytotoxic effect on virus-infected cells.


Inhibits B-cell response to interleukin-4, inhibits IgE production and expression of CB23 antigen. It is an inducer of apoptosis of differentiated B-cells, giving rise to autoreactive clones. Cancels the suppressive effect of interleukin-4 on interleukin-2-dependent proliferation and generation of activated killer lymphokines. It activates the production of proteins of the acute phase of inflammation, enhances the expression of genes C2 and C4 components of the complement system.


Unlike other interferons, it increases the expression of MHC antigens of both class I and II on different cells, and induces the expression of these molecules even on those cells that do not express them constitutively. This increases the efficiency of the presentation of antigens and the ability of their recognition by T-lymphocytes.


Interferon gamma blocks the synthesis of β –TGF, which is responsible for the development of pulmonary and liver fibrosis.


Indications

Prevention and treatment (as part of complex therapy) of influenza.


Prevention and treatment (as part of complex therapy) of influenza H5N1 and H1N1.


Contraindications

Individual intolerance to interferon gamma or any other component of the drug.


Pregnancy.


Children's age (under 7 years old).


Application during pregnancy and lactation

Contraindicated in pregnancy.


Composition

Active substances:


Interferon gamma - 100,000 IU (5.5 ± 0.5).


Excipients:


mannitol


Description


The drug is a loose or porous white mass, hygroscopic.


Method of administration and dosage

Intranasally. The contents of the vial are dissolved in 5 ml of water for injection.


At the first signs of influenza, ARVI, 2 drops in each nasal passage after using the toilet of the nasal passages 5 times a day for 5 to 7 days.


For the prevention of acute respiratory viral infections and influenza in contact with a patient and / or hypothermia


2 - 3 drops in each nasal passage every other day 30 minutes before breakfast for 10 days.


If necessary, preventive courses are repeated. With a single contact, one instillation is sufficient.


After instillation, it is recommended to massage the wings of the nose with your fingers for several minutes to evenly distribute the drug in the nasal cavity.


Side effects

Not marked.


Storage conditions

Store in a dry, dark place and out of reach of children, at a temperature not higher than + 25 ° C.


Store the drug solution for no more than 10 days in the refrigerator (do not freeze).


Shelf life

2 years.


Active substance

Interferon gamma human recombinant


Dosage form

nasal drops


Indications

Joint pain, Eczema, Atopic dermatitis

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Ingaron lyof d / prig intranasal solution introduced 100 thousand IU bottle 1 pc.

  • Product Code: ES 87964533445
  • Registration Date : 27/07/2021
    Number Of Products : 20633
    Top Rated Seller


  • Availability: In Stock
  • $25.10


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